Melissa "Issa" Alie

Issa is the predominant female character in Least I Could Do. Unlike most other women in the comic, she has never had sex with Rayne, despite his many advances. Despite this, the two have remained friends since they were teenagers, and along with Noel, she is Rayne's best friend. She has a job at IDS and is currently in a relationship with Archie.

In the commentary included in LICD: Noir et Blanc, Sohmer reveals that Issa is meant to bear a resemblance to former porn star Erica Campbell. Ironically, Ms Campbell retired from porn after becoming a born-again Christian.